Mutated WT1, FLT3-ITD, and NUP98-NSD1 Fusion in Various Combinations Define a Poor Prognostic Group in Pediatric Acute Myeloid Leukemia

Figure 2

Co-occurrence of WT1 and FLT3-ITD mutations at initial diagnosis of pediatric AML predicts poor survival outcomes. (a) WT1 mutation as single factor increased the incidence of relapse, reducing the probability of survival. (b) The presence of FLT3-ITD, individually, leads to an increased chance of relapse and decreased patient survival. (c) Clinical consequences of WT1 mutations and FLT3-ITD were dependent on each other. WT1, Wilms Tumor 1; FLT3-ITD, fms related tyrosine kinase 3-internal tandem duplication; pEFS, probability of event-free survival; pOS, probability of overall survival; CIR, cumulative incidence of relapse; SE, standard error; n, number. No response to treatment was considered as the occurrence of an event at time zero.