Lung Cancer and Human Papilloma Viruses (HPVs): Examining the Molecular Evidence
Figure 3
E7-dependent tumorigenic signaling. Diagram summing up the steps targeted by the viral protein E7 in the tumorigenesis of the lung tissue. The histone deacetylases (HDAC) gets released from the retinoblastoma protein (pRb), elongation factor (E2F), and HDAC complex when E7 binds to it and leads to the downregulation of tumor-suppressor- A protein by hypermethylation thus leading to tumorigenesis.
