The Role of FoxC2 Transcription Factor in Tumor Angiogenesis
Figure 1
Tumor development and angiogenesis are impaired in FoxC2+/– mice. (a) Subcutaneous growth of B16 melanoma cells in WT and FoxC2+/– mice 11 days after injection. The yellow arrow identifies a smaller tumor in a FoxC2+/– mouse. (b) A difference in tumor weight between WT and FoxC2+/– mice was observed 11 days after the injection of B16 melanoma cells. The data are from five independent experiments and are presented as . Statistical significance was evaluated with Student’s -test. * versus WT. (c, d) Tumor angiogenesis is reduced in FoxC2+/– mice. (c) The total number of capillaries was calculated by counting PECAM-1-positive endothelial cells in B16 tumors. Statistical significance was evaluated with Student’s -test (* versus WT). (d) Total vessel density was calculated by measuring the evaluated with the Student’s -test PECAM-1-positive vessel area. Statistical significance was evaluated with Student’s -test. * versus WT. Adapted from Sano et al. [15].
