Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review

Table 7

Intra- and intergroup effects of ADAS-Cog.

Study	IG (pre)	IG (post)	IG difference	p (pre-post)	CG difference	IG-CG difference	p IG-CG
Gandotra and Kour [45]	51.3 + 14.8	47.2 + 16.3	−4.1	0.001	—	—	—
Henderson et al. [54]
ITT	—	—	−0.313	—	+1,227	+1.54	0.0767
APOE^−	—	—	−1.747	—	+1.614	+3.36	0.0148
APOE^+	—	—	+0.868	—	+0.989	+0.12	0.9211
PP	—	—	−0.563	—	+0.956	+1.52	0.1923
APOE^−	—	—	−2.426	—	+1.963	+4.39	0.0143
APOE^+	—	—	+1.433	—	+0.145	−1.29	0.4307
DC	—	—	−1.182	—	+1.076	+2.26	0.0641
APOE^−	—	—	−3.864	—	+1.472	+5.33	0.0063
APOE^+	—	—	+0.909	—	+0.833	+0.08	0.9635
Henderson et al. [55]
APOE^−	22.1 + 9.11	23.172	+1.072	—	+0.311	−0.761	0.245
APOE^+	—	—	+1.235	—	+1.217	−0.018	0.987
Newport et al. [41] case report	—	—	−6.0	—	—	—	—
Ohnuma et al. [42]	22.4 + 13.2
APOE^−	23.1 + 13.3	23.08	−0.02	>0.05	—	—	—
APOE^+	22.7 + 14.4	22.6	−0.10	>0.05	—	—	—
Rebello et al. [60]
APOE^−	5	10	+5	—	0	5	—
APOE^+	18	14	−4	—	−4	0	—
Reger et al. [39]
APOE^−	—	—	−1.6	0.04	—	—	—
APOE^+	—	—	+1.0	>0.05	—	—	—
Xu et al. [50]	22.23 + 10.80	18.77 + 8.74	−2.47	<0.01	+2.48	−4.95
APOE^−	22.37 + 10.81	19.75 + 8.65	−2.62	<0.01	+2.57	−5.19	<0.01
APOE^+	20.23 + 12.69	20.10 + 12.34	−0.13	>0.5	+1.10	−1.23	>0.5

Calculated from the data. Estimated from the figure. IG = intervention group; CG = control group; ITT = intention to treat; PP = per protocol; DC = dosage compliant; APOE−/+ = APOE positive/negative.