Review Article
Medium-Chain Triglycerides (MCTs) for the Symptomatic Treatment of Dementia-Related Diseases: A Systematic Review
Table 5
Plasma concentration of β-hydroxybutyrate (mmol/L) in the intervention groups.
| | Preintervention | Postintervention | Difference (%) | |
| β-hydroxybutyrate (mmol/L) | Preprandial vs. postprandial | CroteauC8 [56] | 0.220 ± 0.180 | 0.570 ± 0.270 | +159 | 0.075 | CroteauC8C10 [56] | 0.200 ± 0.150 | 0.460 ± 0.190 | +130 | 0.021 | Fortier et al. [57] | 0.207 ± 0.133 | 0.543 ± 0.321 | +162 | 0.001 | Fortier et al. [48] | 0.149 ± 0.134 | 0.401 ± 0.303 | +169 | — | Henderson et al. [54] | ∼0.090 | 0.390 | +333 | — | Henderson et al. [55] | 0.122 ± 0.11 | 0.250 ± 0.142 | +105 | — | Ohnuma et al. [42] | 0.081 ± 0.799 | 0.250 ± 0.206 | +209 | — | OtaRCT [49] | 0.065 ± 0.059 | 0.471 ± 0.293 | +625 | <0.05 | Roy et al. [47] | 0.210 ± 0.136 | 0.572 ± 0.325 | +172 | <0.001 | Xu et al. [50] | 0.393 ± 0.234 | 0.902 ± 0.746 | +130 | <0.01 | [39] | 0.040 ± 0.020 | 0.540 ± 0.320 | +1250 | — | [39] | 0.080 ± 0.080 | 0.680 ± 0.360 | +750 | | Preprandial vs. preprandial | Juby et al. [43] | 0.190 | 0.220 | +16 | a | Henderson et al. [54] | ∼0.090 | ∼0.100 | +11 | a† | Henderson et al. [55] | 0.122 ± 0.110 | 0.128 ± 0.100 | +5 | — | OtaOLE [49] | 0.068 ± 0.064 | 0.106 ± 0.157 | +56 | 0.69 | Acetoacetate (mmol/L) | Preprandial vs. postprandial | CroteauC8 [56] | 0.140 ± 0.110 | 0.250 ± 0.070 | +79 | 0.173 | CroteauC8C10 [56] | 0.110 ± 0.080 | 0.210 ± 0.100 | +91 | 0.014 | Fortier et al. [57] | 0.123 ± 0.056 | 0.272 ± 0.141 | +121 | 0.001 | Fortier et al. [48] | 0.092 ± 0.062 | 0.205 ± 0.136 | +123 | — | Ohnuma et al. [42] | 0.035 ± 0.027 | 0.079 ± 0.049 | +126 | — | OtaRCT [49] | 0.031 ± 0.022 | 0.138 ± 0.069 | +345 | <0.05 | Roy et al. [47] | 0.124 ± 0.054 | 0.286 ± 0.142 | +131 | <0.001 | Xu et al. [50] | 0.137 ± 0.067 | 0.257 ± 0.150 | +88 | <0.01 | Preprandial vs. preprandial | OtaOLE [49] | 0.033 ± 0.024 | 0.043 ± 0.040 | +30 | 0.66 |
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Estimated from figure. Significant between-group effect; values rounded to three decimals. Nonsignificant between-group effects are shown in bold. RCT = randomized controlled trial; OLE = open-label extension; C8 = supplement containing only caprylic acid; C8C10 = supplement containing caprylic and capric acid. |