Metabolic Differences between Dogs of Different Body Sizes

Table 1

Plasma metabolites with adjusted value < 0.05 between small dogs and dogs of larger body size.

Metabolite name	Ratio (small/larger)	Class	Adj. P	RI	Mass
Creatine	2.81	Amino acid		758	132.1
Creatinine	0.78	Amino acid		730	114.1
5-Oxoproline	0.78	Amino acid		744	128.2
gamma-Glutamylphenylalanine	0.71	Peptide		2846	295.1
X-18487	0.48	Unnamed		1269.6	273.1
Hydroxyproline	0.72	Amino acid		705	132.1
Phenylalanine	0.84	Amino acid		2056	166.1
X-14625	0.82	Unnamed		742	308.1
X-17381	2.94	Unnamed		4159.8	293.1
p-Cresol sulfate	1.48	Amino acid		2896	187.1
X-11334	0.47	Unnamed		982	259.1
Urate	0.72	Nucleotide		1928	441.2
X-13731	1.92	Unnamed		1902	235
gamma-Glutamylisoleucine	0.78	Peptide		2644	261.2
gamma-Glutamylleucine	0.76	Peptide		2744	261.2
gamma-Glutamylvaline	0.77	Peptide		2040	247.2
Pseudouridine	0.89	Nucleotide		1104	243.1
Phenol sulfate	1.74	Amino acid		2150	173.1
X-12668	1.72	Unnamed		2318	246.1
C-Glycosyltryptophan	0.79	Amino acid		1912	367.1
myo-Inositol	0.79	Lipid	0.001	1924.9	217
17-Methylstearate	1.42	Lipid	0.001	5987	297.4
X-14314	0.79	Unnamed	0.001	2302	241.1
Glutamine	0.89	Amino acid	0.002	684	147.2
X-12010	0.72	Unnamed	0.002	1707	203.1
Glycolate (hydroxyacetate)	0.87	Xenobiotics	0.002	1119	177
gamma-Glutamyltyrosine	0.75	Peptide	0.002	2073	311.2
X-12822	0.62	Unnamed	0.004	2786	389.1
Xylonate	0.58	Carbohydrate	0.004	1722	292
Prolylhydroxyproline	0.19	Peptide	0.005	960	229.2
Mannitol	0.33	Carbohydrate	0.005	1839	319.1
Hydroquinone sulfate	1.57	Xenobiotics	0.005	1383	189
Ethanolamine	0.61	Lipid	0.005	1304	174.1
4-Ethylphenyl sulfate	1.50	Xenobiotics	0.006	3570	201.1
Arabonate	0.69	Cofactors and vitamins	0.006	1736	292.1
N6-Carbamoylthreonyladenosine	0.87	Nucleotide	0.006	2656	413
Pantothenate (Vitamin B5)	1.32	Cofactors and vitamins	0.006	2218	220.1
Pyroglutamine	0.74	Amino acid	0.006	764	129.2
gamma-Glutamylmethionine	0.77	Peptide	0.008	1993	279.2
X-16940	3.45	Unnamed	0.010	1694.1	204.9
Citrulline	1.21	Amino acid	0.010	715	176.1
Tyrosine	0.86	Amino acid	0.010	1516	182.1
Gulono-1,4-lactone	0.68	Cofactors and vitamins	0.011	1862	333.1
Methylpalmitate (15 or 2)	1.23	Lipid	0.011	5698	269.4
X-16394	0.79	Unnamed	0.011	1719	229.2
Xylitol	0.75	Carbohydrate	0.014	1677.6	217
Arginine	1.15	Amino acid	0.015	728	173.2
2′-Deoxycytidine	0.84	Nucleotide	0.021	1256	228
2′-O-Methylguanosine	0.59	Nucleotide	0.022	1926	298
Ophthalmate	0.47	Amino acid	0.023	1457	290.1
Homocitrulline	0.77	Amino acid	0.024	832	190.1
5-Methylcytidine	1.13	Nucleotide	0.025	1388	258
N-Formylmethionine	0.89	Amino acid	0.029	1541	176.1
Bilirubin (E,E)	0.50	Cofactors and vitamins	0.031	4625	585.2
X-17299	0.83	Unnamed	0.031	1265.9	229.2
X-18156	0.79	Unnamed	0.031	1392	272.1
Palmitoyl sphingomyelin	0.84	Lipid	0.032	2524	311.3
X-16945	1.73	Unnamed	0.036	3457.9	351
Cysteine-glutathione disulfide	0.81	Amino acid	0.038	821	427.1
4-Vinylphenol sulfate	1.29	Xenobiotics	0.040	3323	199.1
Erythritol	0.87	Xenobiotics	0.040	1517.5	217
Dihomolinolenate (20:3n3 or 3n6)	1.19	Lipid	0.043	5600	305.4
Anthranilate	1.36	Amino acid	0.049	3213	138.1
Lysine	0.75	Amino acid	0.049	1836.7	317.2
Threitol	0.86	Carbohydrate	0.049	1513	217.1
Threonate	0.74	Cofactors and vitamins	0.049	1560.7	292.1

Ratios of median transformed values, Benjamini-Hochberg adjusted values, metabolite biological class, retention index (RI), and mass (Da) are shown. X-##### metabolites represent distinct chemical entities of discrete molecular formula and structure but do not currently match a named biochemical in our reference library.