Downregulation of PGC-1α Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice

Figure 6

Effect of long-term EET-A treatment on the expression of genes involved in mitochondrial biogenesis and dynamics in adipose tissue of mice fed HF diet. Representative Western blots (a). Densitometry analysis of MnSOD (b), UCP1 (c), TFAM, (d) protein levels, and COX-IV mRNA levels (e) in adipose tissues of lean, HF diet fed (HF), and HF diet EET-A-treated (EET-A) mice. Results are mean ± SE, , versus lean, versus HF.

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