Clinical Study

Inflammatory and Oxidative Stress Responses to High-Carbohydrate and High-Fat Meals in Healthy Humans

Table 1

Baseline characteristics of study participants with (FH+) and without (FH−) a family history of T2D.

FH−FH+

N (Male/Female)7 (2/5)8 (2/6)
Age (years)41 ± 347 ± 2
Weight (kg) 7 5 . 5 ± 5 . 5 6 9 . 5 ± 3 . 3
BMI (kg/m2) 2 6 . 5 ± 2 . 1 2 6 . 0 ± 1 . 9
Total body fat (%)36 ± 436 ± 4
Abdominal fat (kg) 2 . 5 ± 0 . 4 1 . 9 ± 0 . 3
Total cholesterol (mmol/L) 4 . 6 ± 0 . 3 5 . 1 ± 0 . 2
HDL cholesterol (mmol/L) 1 . 2 ± 0 . 0 8 1 . 3 ± 0 . 0 7
LDL cholesterol (mmol/L) 2 . 9 ± 0 . 2 3 . 2 ± 0 . 1 5
Triglycerides (mmol/L) 1 . 1 ± 0 . 2 1 . 3 ± 0 . 2
GIR (μmol min−1/kg FFM) 7 8 . 7 ± 9 . 3 7 3 . 5 ± 9 . 2
Glucose iAUC (CHO)429 ± 65492 ± 55
Glucose iAUC (Fat)43 ± 1353 ± 16
Insulin iAUC (CHO)15924 ± 319031081 ± 3993*
Insulin iAUC (Fat)1895 ± 3923379 ± 322*

Data are given mean ± SEM, GIR: Glucose infusion rate necessary to maintain euglycemia during the hyperinsulinemic clamp; AUC: area under the curve, * 𝑃 < 0 . 0 2 .