Solidifying Fenofibrate Nanocrystal Suspension: A Scalable Approach via Granulation Method

Table 2

Formulation design for solidification process (batch size of 20 g).

Formulation	Feno : FLR (w : w)	Nanosuspension eq. Feno (mg)	Ingredients for adsorbent (mg)			Adding lactose
			FLR	Lactose	MCC
Mixing method
F41	4 : 1	145	36.25			350
F43	4 : 3	145	108.75			277
F45	4 : 5	145	181.25			205
F41-CT1	4 : 1	145	36.25		145	205
F41-CT2	4 : 1	145	36.25	72.5		277
F41-CT3	4 : 1	145	36.25	72.5	145	132
Granulation method
P33	3 : 3	145	145
P38	3 : 8	145	386.67
P315	3 : 15	145	725
P38-CT3	3 : 3	145	145	80.5	161
P38-CT4	3 : 0	145	0	133	266

Feno was in form of nanosuspension. The ratio of lactose: MCC was selected according to F41-CT3.