A Sequence-Dependent DNA Condensation Induced by Prion Protein

Figure 11

The ultrastructure of DNA-PrP interaction was analysed by scanning electron microscopy (SEM) technology. The electron microscopy generated morphology of gcDNA (5 μM DNA-phosphate) alone and after addition of α-PrP (12 μM; 1 minute of incubation) to it ((a) and (b)). The scale bar represents 500 nm. Morphology of atDNA (5 μM DNA-phosphate) alone and morphology of with α-PrP (12 μM) after 1 minute of incubation ((c) and (d)). The scale bar represents 200 nm. A clear condensed gcDNA structure was observed in the presence of α-PrP (b).

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(b)

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