On Characterizing the Interactions between Proteins and Guanine Quadruplex Structures of Nucleic Acids

Figure 2

X-ray structures of HD22-27mer (a) and RE31 (b) guanine quadruplex-containing aptamers bound to thrombin, for ease of differentiating the thrombin binding sites: shown in red ribbon is the light chain of thrombin and shown in grey ribbon is the heavy chain of thrombin with the C-terminal nub of the heavy chain shown in red. DNA aptamers are shown in blue. PDBs 4I7Y (a) and 5CMX (b).

(a)

(b)