Cell-SELEX Identifies a “Sticky” RNA Aptamer Sequence

Figure 4

The sequence alignments of M7-14 and the variable region (VR) of the C3 aptamer [5]. The sequences were analyzed by using Multalign [9] program; 64% of the nucleotides were identical between the C3 VR and the M7-14 VR. The nucleotides that are identical between the two sequences are denoted in red font. The secondary structure of the aligned sequences for (b) M7-14 and (c) C3 VR, as predicted by the M-fold [7], identifies a common structural motif.

(a)

(b)

(c)