Research Article

Expression of Genes and Their Polymorphism Influences the Risk of Knee Osteoarthritis

Table 2

Genotype association between 3 SNPs in CALM-1 gene and knee osteoarthritis.

All subjects Women Men
Control (%)
500
Case (%)
500
OR, (95% CI), valueControl (%)
276
Case (%)
295
OR, (95% CI), valueControl (%) 224Case (%)
205
OR, (95% CI), value

Genotype
 ApaLI (rs 12885713)
  CC125 (25)102 (20.4)1.00, (Ref)70 (25.36)62 (21.01)1.00, (Ref)55 (24.55)40 (19.51)1.00, (Ref)
  CT233 (46.6)240 (48)1.26, (0.91–1.73), 0.150119 (43.11)117 (39.66)1.11, (0.72–1.70), 0.631114 (50.89)123 (60.00)1.48, (0.91–2.39), 0.106
  TT142 (28.4)158 (31.6)1.36, (0.96–1.92), 0.07887 (31.5)116 (42.02)1.50, (0.96–2.33), 0.06855 (24.55)42 (20.48)1.05, (0.59–1.86), 0.867

Allele
 rs 12885713
  C483 (48.3)444 (44.4)1.00, (Ref)259 (46.92)241 (40.84)1.00, (Ref)224 (50.00)203 (49.51)1.00, (Ref)
  T517 (51.7)556 (55.6)1.17, (0.98–1.39), 0.080293 (53.07)349 (59.15)1.28, (1.01–1.61), 224 (50.00)207 (50.48)1.02, (0.78–1.33), 0.886

Genotype
 ApeKI (rs 3814843)
  TT477 (95.4)444 (88.8)1.00, (Ref)259 (93.8)258 (87.45)1.00, (Ref)218 (97.32)186 (90.73)1.00, (Ref)
  TG23 (4.6)56 (11.2)2.61, (1.58–4.32), 17 (6.1)37 (12.55)2.18, (1.2–3.98), 06 (2.67)19 (9.26)3.71, (1.45–9.48),
  GG

Allele
 rs 3814843
  T977 (97.7)944 (94.4)1.00, (Ref)535 (96.92)553 (93.72)1.00, (Ref)442 (98.66)391 (95.36)1.00, (Ref)
  G23 (2.3)56 (5.6)2.52, (1.53–4.12), 17 (03.07)37 (06.27)2.10, (1.17–3.78), 06 (01.33)19 (04.63)3.46, (1.39–8.57),

Genotype
 rs 2300496
  AA167 (33.4)147 (29.4)1.00, (Ref)86 (31.15)80 (27.11)1.00, (Ref)81 (36.16)67 (32.68)1.00, (Ref)
  AC220 (44)221 (44.2)1.14, (0.85–1.52), 0.371125 (45.28)132 (44.74)1.13, (0.76–1.67), 0.52495 (42.41)89 (43.41)1.13, (0.73–1.74), 0.573
  CC113 (22.6)132 (26.4)1.32, (0.94–1.85), 0.09765 (23.55)83 (28.13)1.37, (0.88–2.14), 0.16248 (21.42)49 (23.90)1.23, (0.73–2.06), 0.421

Allele
 rs 2300496
  A554 (55.4)515 (51.5)1.00, (Ref)297 (53.84)292 (49.49)1.00, (Ref)257 (57.36)223 (56.82)1.00, (Ref)
  C446 (44.6)485 (48.5)1.17, (0.98–1.39), 0.080255 (46.19)298 (50.50)1.18, (0.95–1.5), 0.145191 (42.63)187 (45.60)1.12, (0.86–1.47), 0.380

OR, odds ratio; 95% CI, 95% confidence interval; Ref, reference category; p < 0.05 is considered statistically significant.