Role of Eukaryotic Initiation Factors during Cellular Stress and Cancer Progression

Table 1

Differential expression of eIF3 subunits in human cancers and notable eIF3-protein interactions.

eIF3 Subunit	Expression	Cancer associations	Protein interactions
eIF3a		Breast, cervix, esophagus, lung & gastric [89, 90]	ribonucleotide reductase M2 [91], RARα [92], Raf-1 [93]
eIF3b		Breast, bladder & prostate [90]	mTOR/S6K1 [94], ICP27 [95], DDX3 [96], NREP [97]
eIF3c		Colon [98], meningioma [99] & testicular seminomas [100]	mTOR/S6K1 [94], MAPK6 [101], CDK2 [102], TARDBP [103], schwannomin [99]
eIF3d		Colon [104, 105], gastric [70] & mesothelioma [70]	hTDAG51 [106], VPg [107]
eIF3e		Breast & lung [89, 90]	S6K1 [94], DDX3 [96], Rpn5 [108]
eIF3f		Breast, colon, melanoma & pancreas [90, 109]	mTOR [110], S6K1 [111], HnRNP K [109]
eIF3h		Breast, colon, liver & prostate [89, 90]	Acetylated HIV-1 IN [112], MGMT [113]