Apolipoprotein E2 Genotype Is Associated with a 2-Fold Increase in the Incidence of Type 2 Diabetes Mellitus: Results from a Long-Term Observational Study

Table 1

Frequency of APOE genotype and APOE allele by gender.

	Total	Male	Female
	(N=444)	(N=259)	(N=185)
Genotype; E2/2 – no. (%)	11 (2.5)	7 (2.7)	4 (2.2)
E3/2 – no. (%)	40 (9.0)	25 (9.7)	15 (8.1)
E 4/2 – no. (%)	8 (1.8)	4 (1.5)	4 (2.2)
E3/3 – no. (%)	283 (63.7)	163 (62.9)	120 (64.9)
E4/3 – no. (%)	91 (20.5)	54 (20.8)	37 (20.0)
E4/4 – no. (%)	11 (2.5)	6 (2.3)	5 (2.7)
Allele
E2 – no. (%)	70 (7.9)	43 (8.3)	27 (7.3)
E3 – no. (%)	697 (78.5)	405 (78.2)	292 (78.9)
E4 – no. (%)	121 (13.6)	70 (13.5)	51 (13.8)