Developing a Modified Low-Density Lipoprotein (M-LDL-C) Friedewald’s Equation as a Substitute for Direct LDL-C Measure in a Ghanaian Population: A Comparative Study
Table 3
Means ± SDs and percentages of correctly classified subjects in risk categories regarding TC, TG and D-LDL-C concentrations given by NCEP ATP III.
of subjects correctly classified by the following formulas
TC (mmol/L)
n
D-LDL-C
F-LDL-C
N-LDL-C
A-LDL-C
M-LDL-C
F
N
A
M
≤4.13
586
2.01±0.53
1.91±0.40
1.89±0.40
2.11±0.38
2.09±0.41
77.6%
77.9%
92.6%
86.4%
4.14-5.16
536
2.49±0.51
2.79±0.41
2.77±0.39
3.04±0.31
2.99±0.40
78.1%
77.9%
84.1%
78.9%
5.17-6.20
272
2.92±0.50
3.52±0.45
3.52±0.41
3.80±0.36
3.78±0.42
72.4%
76.4%
65.6%
64.6%
6.21-7.24
89
3.44±0.65
4.45±0.49
4.43±0.44
4.66±0.38
4.72±0.45
65.8%
70.3%
56.9%
48.1%
≥ 7.25
35
3.90±0.66
6.16±2.18
6.17±2.18
6.37±1.84
6.53±2.21
63.8%
68.9%
59.6%
50.8%
TG (mmol/L)
≤1.13
1055
2.40±0.69
2.63±0.90
2.57±0.89
2.92±0.91
2.78±0.91
75.2%
79.1%
73.0%
80.6%
1.14-1.69
324
2.61±0.70
2.96±0.90
3.10±0.93
3.10±0.99
3.24±0.96
30.2%
32.4%
29.3%
29.6%
1.70-2.25
76
2.75±0.69
3.18±1.20
3.30±0.89
3.29±1.20
3.58±1.19
19.7%
23.7%
25.0%
22.4%
2.26-2.82
40
2.68±0.75
3.49±2.82
3.74±2.74
3.51±2.49
4.01±2.82
11.4%
5.0%
2.5%
10.0%
2.83-4.52
23
2.74±1.01
3.00±1.05
3.43±0.96
3.03±1.02
3.75±1.07
4.3%
8.7%
8.7%
17.4%
LDL-C (mmol/L
≤2.59
903
2.01±0.38
2.33±0.65
2.31±0.65
2.61±0.68
2.53±0.67
80.0%
80.4%
80.0%
81.4%
2.60-3.35
447
2.92±0.22
3.05±0.90
3.04±0.89
3.23±0.88
3.27±0.92
41.4%
42.9%
31.7%
34.1%
3.36-4.12
142
3.62±0.18
3.98±0.91
3.95±0.92
4.18±0.93
4.22±0.97
31.9%
31.4%
19.2%
22.6%
4.13-4.89
21
4.36±0.21
5.68±2.54
5.64±2.57
5.72±2.26
5.94±2.26
8.2%
9.5%
9.8%
42.5%
≥4.90
5
5.54±0.44
6.08±2.12
6.06±2.69
6.07±2.69
6.40±2.06
10.6%
8.8%
3.5%
7.7%
p<0.05,p<0.0001: significant compared to D-LDL-C. TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein cholesterol; LDL-C: low-density lipoprotein cholesterol; D-LDL-C: directly measured LDL-C; FLDL-C, LDL-C calculated by Friedewald’s formula; N-LDL-C, LDL-C calculated by Martin’s formula; A-LDL-C, LDL-C calculated by Anandaraja’s formula; M-LDL-C, LDL-C calculated by modified formula.
