Following the growing interest on complex inflammatory processes, intense research is going on to establish its role in human diseases. The immune system triggers an array of inflammatory reactions as a response to any exogenous and/or endogenous homeostasis disturbing factors. These processes are vital to preserve cells, tissues, and organ integrity, but since they comprise complex elements, regulation of this array of events is the main key for maintaining a normal physiological, efficient process. Regulatory mechanisms, some of them still unknown, are needed to balance the immune response. Thus, an insufficient response may cause immunodeficiency resulting in infection, cancer, neurodegeneration and various other human diseases.

The aim of this Special Issue is to collate original research and review articles that tackle chronic inflammation triggering/favoring oncogenesis of solid tumors, as well as those reporting the inflammation process as a mechanism for efficient immune therapy in oncology. We invite investigators to contribute with reviews and original papers describing recent findings in oncology field with focus on inflammation as part of the problem or part of the solution in tumor process/disease evolution.

Potential topics include but are not limited to the following:

• Proteomics/immunoproteomics biomarkers for monitoring inflammation in skin cancer, brain cancer, and other types of tumors
• The innate-adaptive immune systems interface in inflammation
• Signaling inflammation-mediated events as tumorigenesis triggers
• Inflammasomes in cancer
• Inflammation and transcriptomics
• Epigenetics of inflammation
• New methodological approaches for inflammation evaluation in cancer
• New avenues of immune therapy in cancer
• Personalized medicine through inflammatory status evaluation
• Bioinformatics: main tool for human inflammasome approaches
• Inflammaging as tumorigenesis trigger
• Environmental triggers of inflammation leading to oncogenesis