Omics is the systematic study of genes, metabolism, or proteins. With the development of Next Generation Sequencing and single-cell technology, the study of omics has gradually improved. In the case of immune related diseases, such as tumours and autoimmune diseases, the study of only one ‘omics’ is no longer enough to clearly explain their pathogenesis, and hence the joint study of multiple omics has become the future trend. Bioinformatics facilitates the intersection of omics.

The combination of transcriptomics and metabolomics has identified key microbial dysfunction and host factors for inflammatory bowel disease (IBD), and the integration of multi-omics has enabled prediction of cytokine responses. Despite this existing research, further studies on immune-related diseases need to be carried out by applying multi-omics techniques to explore the pathogenesis, diagnostic markers, and potential therapeutic targets of the disease.

The aim of this Special Issue to collate original research articles that provide insight into the multi-omics study of immune related diseases. Review articles discussing the current state of the art are also welcomed.

Potential topics include but are not limited to the following:

• The prospects and difficulties of multi-omics studies in autoimmune diseases
• Application of multi-omics in the differentiation and regulation of immune cells
• Single-cell technology to explore changes in immune cell subtypes in autoimmune diseases
• Use of micro-omics to identify diagnostic markers and therapeutic targets for immune diseases
• Application of bioinformatics analysis in the diagnosis and treatment of autoimmune diseases