Circadian Regulator-Mediated Molecular Subtypes Depict the Features of Tumor Microenvironment and Indicate Prognosis in Head and Neck Squamous Cell Carcinoma

Figure 3

HNSCC patients exhibited three circadian rhythm-related subtypes with distinct prognosis and TME. (a) Consensus clustering matrix of HNSCC patients for . (b) Expression of 13 CRGs in three CRPs. (c) Survival analysis for three CRP subtypes. (d) An alluvial diagram depicting the relationship between CRP and clinical features (; ; ; ; ; ; ; ; ; and ). (e) Boxplots depicted the differences in immune scores in the three clusters. (f, g) Different immune cell component among three CRP subtypes as determined by CIBERSORT and ssGSEA. Ns: not significant; : ; : ; : .

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