HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population

Table 3

HLA-III haplotype frequencies between PSS patients and healthy controls.

	Frequency (%)				OR (95% CI)
	PSS ()	Control ()
HSP70-1 rs1008438-rs562047-rs12190359
CCT	0.33	3.28	0.006	0.024	0.10 (0.01-0.76)
CCC	10	6.83	0.139	0.278	1.52 (0.87-2.64)
CGC	29.33	29.51	0.961	1.000	0.99 (0.71-1.39)
AGC	60.330	60.38	0.990	0.990	1.00 (0.73-1.36)
HSP70-2 rs2763979-rs6457452
TT	2.67	6.01	0.038	0.114	0.43 (0.19-0.98)
TC	21.33	18.85	0.426	0.639	1.17 (0.80-1.71)
CC	76.00	75.14	0.797	0.797	1.05 (0.73-1.50)
HSP70 rs2227956-rs1043618-rs1008438-rs562047-rs12190359-rs2763979-rs6457452
ACCCTTT	0.34	3.32	0.006	0.048	0.10 (0.01-0.76)
ACCGCCC	15.31	14.90	0.913	0.913	1.02 (0.67-1.57)
ACCGCTC	5.56	4.71	0.551	1.000	1.23 (0.62-2.46)
AGAGCCC	38.14	36.47	0.659	1.000	1.07 (0.78-1.47)
ACCCCTC	9.10	6.09	0.142	0.568	1.55 (0.86-2.78)
GGAGCCC	23.16	24.31	0.691	0.921	0.93 (0.65-1.33)
AGCGCTC	7.14	8.27	0.563	1.000	0.84 (0.47-1.51)
ACCGCTT	1.26	1.93	0.762	0.871	0.69 (0.20-2.39)
TNF-α rs1799964-rs1800630-rs1799724-rs1800629-rs361525
TCCAG	11.11	6.09	0.020	0.080	1.93 (1.10-3.39)
TCTGG	9.43	12.46	0.186	0.372	0.72 (0.44-1.18)
CACGG	13.80	13.30	0.917	0.917	1.02 (0.66-1.60)
TCCGG	65.66	68.15	0.518	0.691	0.90 (0.65-1.24)
TNF-β rs2857709-rs2844484-rs909253-rs2229092-rs1041981
GGACC	0.67	1.66	0.305	0.407	0.40 (0.08-2.01)
GAAAC	23.08	31.58	0.013	0.052	0.64 (0.46-0.91)
GGAAC	14.05	13.02	0.740	0.740	1.08 (0.69-1.68)
GGGAA	62.21	53.74	0.027	0.054	1.42 (1.04-1.94)
TNF rs2857709-rs2844484-rs909253-rs2229092-rs1041981-rs1799964-rs1800630-rs1799724-rs1800629-rs361525
GAAACTCCGG	13.85	19.38	0.065	0.195	0.68 (0.45-1.03)
GGGAATCCGG	51.69	48.31	0.396	0.475	1.14 (0.84-1.55)
GGGAATCCAG	11.15	6.18	0.029	0.174	1.84 (1.06-3.21)
GGAACCACGG	13.18	11.80	0.538	0.538	1.16 (0.73-1.83)
GAAACTCTGG	9.46	12.64	0.186	0.372	0.72 (0.44-1.18)
GGACCCACGG	0.68	1.69	0.252	0.378	0.40 (0.08-2.01)

The haplotype frequencies were presented as haplotype ratio (%). value was calculated using Chi-squared test or Fisher’s exact test and corrected for multiple testing using the FDR method. : number of subjects; PSS: Posner-Schlossman syndrome; : value; : corrected value; CI: confidence interval; OR: odds ratio; values less than 0.05 are bolded.