HSP70 and TNF Loci Polymorphism Associated with the Posner-Schlossman Syndrome in a Southern Chinese Population
Table 2
HLA-III allele frequencies in PSS cases and controls.
Gene
Variants
Location region
Functional annotation
Allele
PSS ()
Control ()
OR (95% CI)
HSP70-1
rs1008438
Upstream
TFBS
C
119 (39.67)
145 (39.62)
0.990
0.990
1.00 (0.73-1.37)
A
181 (60.33)
221 (60.38)
rs562047
Exonic (nonsynonymous)
nsSNP
C
31 (10.33)
37 (10.11)
0.924
1.000
1.03 (0.62-1.70)
G
269 (89.67)
329 (89.89)
rs12190359
Exonic (nonsynonymous)
TFBS
T
1 (0.33)
12 (3.28)
0.006
0.018
0.10 (0.01-0.76)
C
299 (99.67)
354 (96.72)
HSP70-2
rs2763979
Upstream
TFBS
T
72 (24.00)
91 (24.86)
0.797
0.797
1.05 (0.73-1.50)
C
228 (76.00)
275 (75.14)
rs6457452
5UTR
TFBS
T
8 (2.67)
22 (6.01)
0.038
0.076
0.43 (0.19-0.98)
C
292 (97.33)
344 (93.99)
TNF-α
rs361525
Upstream
TFBS
A
3 (1.00)
4 (1.09)
0.860
0.860
1.09 (0.24-4.93)
G
297 (99.00)
362 (98.91)
rs1800629
Intergenic
TFBS
A
33 (11.00)
22 (6.01)
0.020
0.100
1.93 (1.10-3.39)
G
267 (89.00)
344 (93.99)
rs1799724
Intergenic
TFBS
T
29 (9.67)
45 (12.30)
0.283
0.708
1.31 (0.80-2.15)
C
271 (90.33)
321 (87.70)
rs1799964
Downstream
TFBS
C
44 (14.67)
52 (14.21)
0.867
1.000
1.04 (0.67-1.60)
T
256 (85.33)
314 (85.79)
rs1800630
Intergenic
/
A
42 (14.00)
49 (13.39)
0.819
1.000
1.05 (0.68-1.64)
C
258 (86.00)
317 (86.61)
TNF-β
rs909253
Intronic
TFBS
A
114 (38.00)
172 (46.99)
0.020
0.040
1.45 (1.06-1.97)
G
186 (62.00)
194 (53.01)
rs1041981
Exonic (nonsynonymous)
ESE or ESS, nsSNP
C
114 (38.00)
172 (46.99)
0.020
0.033
1.45 (1.06-1.97)
A
186 (62.00)
194 (53.01)
rs2857709
Intronic
/
A
1 (0.33)
5 (1.37)
0.230
0.328
4.14 (0.48-35.64)
299 (99.67)
361 (98.63)
rs2844484
Intronic
TFBS
A
70 (23.33)
119 (32.51)
0.009
0.045
1.58 (1.12-2.24)
G
230 (76.67)
247 (67.49)
rs2229092
Exonic (nonsynonymous)
ESE or ESS, nsSNP
C
2 (0.67)
6 (1.64)
0.305
0.305
2.48 (0.50-12.39)
A
298 (99.33)
360 (98.36)
The allele frequencies were presented as allele count (%). value was calculated using Chi-squared test or Fisher’s exact test and corrected for multiple testing using the FDR method. : number of subjects; PSS: Posner-Schlossman syndrome; : value; Pc: corrected value; CI: confidence interval; OR: odds ratio; TFBS: transcription factor binding sites; ESE: exon splicing enhancer; ESS: exon splicing silencer; nsSNP: nonsynonymous single nucleotide polymorphism. values less than 0.05 are bolded.
