The NLRP3 Genetic Variant (rs10754555) Reduces the Risk of Adverse Outcome in Middle-Aged Patients with Chronic Coronary Syndrome
Table 1
Baseline characteristics in the population () according to occurrence of composite clinical endpoint during two years.
Baseline characteristics
CV endpoints ()
No CV endpoints ()
Age (years, mean (range))
62 (41-80)
63 (36-81)
0.51
Men/women ( (%))
83/23 (78/22)
695/195 (78/22)
0.960
Type 2 diabetes mellitus ( (%))
24 (23)
175 (20)
0.468
Previous MI ( (%))
57 (54)
378 (42)
0.027
Previous stroke ( (%))
6 (6)
20 (2)
0.037
Hypertension ( (%))
63 (59)
493 (55)
0.428
Current smokers ( (%))
23 (22)
178 (20)
0.646
BMI (kg/m2)
26.8 (24.4, 29,9)
27.2 (24.9, 29.6)
0.676
Metabolic syndrome
25 (24)
219 (25)
0.812
Total cholesterol (mmol/L)
4.5 (1.0)
4.6 (1.0)
0.870
HDL cholesterol (mmol/L)
1.3 (0.4)
1.3 (0.4)
0.898
LDL cholesterol (mmol/L)
2.5 (0.8)
2.5 (0.8)
0.749
Triglycerides (mmol/L)
1.25 (1.02, 1.87)
1.32 (0.93, 1.84)
0.869
Fasting glucose (mmol/L)
6.1 (1.7)
6.0 (1.9)
0.931
Medication (%)
Statins
99
98
0.520
β-Blockers
74
76
0.868
Nitrates
27
21
0.154
ACE inhibitors
30
26
0.324
ARB
25
24
0.735
CCB
27
26
0.680
Diuretics
26
23
0.435
Insulin
6
4
0.510
Oral antidiabetics
11
12
0.859
No antidiabetics
8
6
0.454
Values are mean (SD) or number (proportions) if not otherwise stated. MI: myocardial infarction; SD: standard deviation; BMI: body mass index; HDL: high-density lipoprotein; LDL: low-density lipoprotein; ACE: angiotensin converting enzyme; ARB: angiotensin receptor blocker; CCB: calcium channel blocker. values are chi-square test for categorical variables and -test and Mann–Whitney test for continuous variables, referring to differences between patients with and without endpoints. Gem median levels (25 and 75 percentiles). Bolded texts indicate statistical significance.
