Lipopolysaccharide-Induced Transcriptional Changes in LBP-Deficient Rat and Its Possible Implications for Liver Dysregulation during Sepsis

Figure 6

Expression levels of inflammatory indicators in wild-type and LBP-deficient groups after LPS injection. (a, b) Levels of liver enzymes of LDH (a) and ALP (b) levels in serum samples collected at 0 h, 6 h, and 24 h after LPS challenge. Serum LDH and ALP levels were analyzed as a measure of hepatocellular injury. Data are shown as means and standard deviations ( per group at each time point). (c) The percentage of hepatocytes with only nucleus HMGB1 staining out of the total number of hepatocytes was calculated. Data were shown as the . (d) HMGB1 cellular location of liver tissues in the normal rats and LBP^-/- rats at 0 h, 6 h, and 24 h after LPS administration. Original magnification ×400. (e) The expression levels of cleaved-caspase 3 in the wild and LBP^-/- rats at multiple time points after liver LPS injection were assessed using IHC. Original magnification ×400. , , and vs. wild type, significantly different from the wild-type groups.

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