Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study

Table 2

Comparison of sociodemographic, serological, and genetic characteristics of multiple sclerosis patients versus control group.

Variable	Multiple sclerosis	Control group
Female, (%)	76 (65.5)	185 (81.9)	0.001
Age (years)	38 (19-66)	46.0 (21-66)	<0.001
Serum levels
25(OH) vitamin D levels (ng/mL), (%)	16.2 (3.8-50.9)		0.009
Sufficient (>30 ng/mL), (%)	14 (12.0)
Insufficient (20-30 ng/mL), (%)	17 (14.7)		0.009
Deficient (<20 ng/mL), (%)	85 (73.3)
Genetic characteristics
rs10766197, CYP2R1 gene
Genotypes
GG, (%)	43 (37.1)	112 (49.6)
GA, (%)	58 (50.0)	90 (39.8)	0.08
AA, (%)	15 (12.9)	24 (10.6)
Allele
A, (%)	88 (37.9)	138 (30.5)	0.05
G, (%)	144 (62.1)	314 (69.5)	0.05
rs10877012, CYP2B1 gene
Genotypes
GG, (%)	55 (47.4)	101 (44.7)
GT, (%)	48 (41.4)	98 (43.4)	0.90
TT, (%)	13 (11.2)	27 (11.9)
Allele
G, (%)	158 (68.1)	300 (66.4)	0.65
T, (%)	74 (31.9)	152 (33.6)	0.65

For rs10766197 of CYP2R1 gene: GG: wild homozygous; GA: heterozygous; AA: polymorphic homozygous. For rs10877012 of CYP2B1 gene: GG: wild homozygous; GT: heterozygous; TT: polymorphic homozygous. Qualitative variables were expressed as frequency and percentage. Quantitative variables were expressed as median and min-max. Comparisons between medians were performed using Mann–Whitney test. Comparison between proportions was performed using Chi-square test (or Fisher exact test if applicable). values were obtained comparing multiple sclerosis versus control group. Serum levels of 25(OH) vitamin D were determined in 107 healthy controls.