Association of High Calcitriol Serum Levels and Its Hydroxylation Efficiency Ratio with Disease Risk in SLE Patients with Vitamin D Deficiency

Figure 5

Association of vitamin D metabolite serum levels and vitamin D hydroxylation efficiency ratio with the SLE and renal disease activity. (a) Association of vitamin D metabolite serum levels and calcitriol/calcidiol ratio with the SLE (SLE patients vs. HS); (b) association of vitamin D metabolite serum levels and calcitriol/calcidiol ratio with the presence of renal activity. HS: healthy subjects. OR: odds ratio, Fisher’s exact test, blue (protective ) and orange (risk ) graphics, values < 0.05, 95% confidence interval (CI). Black graphics: not significant differences () or high confidence intervals. Calcitriol/calcidiol ratio tertiles: (≥2.23 to 23.6 pg/ng), (≥1.36 to ≤2.23 pg/ng), and (0.01 to <1.36 pg/ng). Calcidiol reference values: deficiency (<20 ng/mL), insufficiency (≥20 to <30 ng/mL), and sufficiency (≥30 ng/mL). Calcitriol tertiles: (≥48.7 to 157.3 pg/mL), (≥33.6 to <48.7 pg/mL), and (0.33 to <33.6 pg/mL).

(a)

(b)