The SIRT3 and SIRT6 Promote Prostate Cancer Progression by Inhibiting Necroptosis-Mediated Innate Immune Response

Figure 2

The higher expression of SIRT3 and SIRT6 in PCa patients is linked to unfavorable outcome. (a) The mRNA expression levels of SIRT3/5/6/7 were correlated with the nodal metastasis of PCa. N0: no reginal lymph node metastasis; N1: metastases in 1 to 3 axillary lymph nodes. , , and . (b) The box plots of expression of SIRT genes in low (green) and high (red) risk groups of TCGA-PRAD patients. -axis: gene expression value of each gene; values are above the box plot. Kaplan-Meier survival plots showed that the high expression of the SIRTs was associated with poor survival in TCGA-PRAD patients. Red: high-risk group; green: low-risk group; top right corner inset: numbers of high- and low-risk samples, numbers of censored samples marked with and CI of each risk group; -axis: time (days); -axis; overall survival probability. (c) Gene alterations in SIRT genes queried from 3801 patients in 16 studies. (d) The frequency of alterations in SIRT genes in 16 individual prostate cancer studies. Genetic alterations in SIRTs were associated with shorter OS of PRAD patients.

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