Meta-Analysis of Expression Profiling Data Indicates Need for Combinatorial Biomarkers in Pediatric Ulcerative Colitis
Table 2
Pathways that overlapped between expression profiling data from two studies of colon biopsies of pediatric ulcerative colitis ( and value < 0.05).
Positive canonical pathway
Activation -score
value
GSE9686
GSE10616
GSE9686
GSE10616
Th1 pathway
4.160
4.012
6.76E-04
1.20E-04
GP6 signaling pathway
3.969
3.429
1.78E-03
4.90E-03
Tec kinase signaling
3.810
2.714
2.34E-03
1.29E-02
IL-8 signaling
3.666
3.349
6.17E-03
1.17E-02
Colorectal cancer metastasis signaling
3.334
2.333
1.66E-03
5.13E-04
TREM1 signaling
3.317
3.651
3.02E-05
3.24E-03
Role of pattern recognition receptors in recognition of bacteria and viruses
3.280
2.746
2.29E-02
1.29E-02
Systemic lupus erythematosus in the T cell signaling pathway
3.200
3.118
3.98E-03
2.69E-03
Production of nitric oxide and reactive oxygen species in macrophages
3.130
3.048
1.23E-02
3.02E-03
PKCθ signaling in T lymphocytes
3.046
2.771
8.13E-03
9.33E-04
Leukocyte extravasation signaling
2.951
2.630
3.72E-07
1.82E-07
Acute phase response signaling
2.898
2.263
6.92E-03
1.38E-03
Neuroinflammation signaling pathway
2.866
2.360
9.12E-03
1.15E-03
Osteoarthritis pathway
2.862
3.022
9.33E-04
1.82E-05
CD28 signaling in T helper cells
2.654
2.271
4.57E-02
2.24E-03
LPS/IL-1-mediated inhibition of RXR function
2.592
2.466
1.45E-05
1.23E-06
Chondroitin and dermatan biosynthesis
2.236
2.236
3.39E-02
6.76E-03
indicates a pathway that has not been described in pediatric UC. GP6: glycoprotein VI; IL-8: interleukin-8; TREM1: triggering receptor expressed on myeloid cell-1; PKCθ: protein kinase C theta; LPS: lipopolysaccharides; IL-1: interleukin-1; RXR: retinoid X receptor.
