The Potential Role of Regulatory B Cells in Idiopathic Membranous Nephropathy

Table 1

Breg found in human peripheral blood.

Name	Breg cell phenotype	Method of stimulation in vitro	Mechanism of suppression	References
B10	CD24^hiCD27^+	CD40L^+CpG, LPS	IL-10	29
Immature B cell	CD24^hiCD38^hiCD27^-	CD40L, CpG^+pDC	IL-10, PD-L1, CD80/CD86	28
GrB^+ B cell	CD38^+CD1d^hiIgM^+CD147^+	IL-21^+ anti-BCR	IL-10, GrB, IDO	30
Tim-1 B cell	Tim-1^+	—	IL-10, TGF-β	31
—	CD39^+CD73^+	CD40L^+IL-4	Adenosine	64
—	IgD^loCD38^+CD24^loCD27^-	—	CD62L	65
Plasmablasts	CD24^hiCD27^intCD38^+	GpG^+IL-2^+IL-6^+IFNα	IL-10	32
Br1 cell	CD25^hiCD71^hi	CpG	IL-10, IgG4	33
B-1 cell	CD27^+CD43^+CD11b^+	—	IL-10, CD80/CD86	34