STK3 Suppresses Ovarian Cancer Progression by Activating NF-<i>κ</i>B Signaling to Recruit CD8<sup>+</sup> T-Cells

<div>Database analysis showed that STK3 was downregulated in ovarian cancer tissues, and the overexpression of STK3 was closely related to better prognosis. (a) Analysis of the mRNA level expression of STK3 in the TCGA database and GEO database (two-tailed Student’s <span class="nowrap"><svg height="8.02022pt" id="M18" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -7.81382 4.54925 8.02022" width="4.54925pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g></svg>-</span>test, <span class="nowrap"><svg height="10.7395pt" id="M19" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 68.3436 10.7395" width="68.3436pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 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443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g><g transform="matrix(.013,0,0,-0.013,73.667,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z"></path></g></svg>).</span> (b) Analysis of the overall survival period and progression-free survival period according to the STK3 expression in the TCGA database and GEO database (log-rank test).</div>

Journal of Immunology Research

fig1

Figure 1

Figure 1: STK3 Suppresses Ovarian Cancer Progression by Activating NF-<i>κ</i>B Signaling to Recruit CD8<sup>+</sup> T-Cells 

Journal of Immunology Research

STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8+ T-Cells

Figure 1

STK3 Suppresses Ovarian Cancer Progression by Activating NF-κB Signaling to Recruit CD8⁺ T-Cells