West Nile Virus Vaccine Design by T Cell Epitope Selection: In Silico Analysis of Conservation, Functional Cross-Reactivity with the Human Genome, and Population Coverage

Table 4

Final epitope combinations corresponding to candidate epitope ensemble vaccine and PPC.

Ensemble	HLA-I epitopes	HLA-II epitopes	PPC (%)
1	ITYTDVLRY TLARGFPFV	VTVNPFVSVATANAKVLI; ILVSLAAVVVNPSVKTVR	96.36
2	ITYTDVLRY TLARGFPFV SYHDRRWCF	VTVNPFVSVATANAKVLI	97.14
3	ITYTDVLRY TLARGFPFV KSYETEYPK	VTVNPFVSVATANAKVLI	95.23
4	ITYTDVLRY TLARGFPFV KSYETEYPK; SYHDRRWCF	VTVNPFVSVATANAKVLI; ILVSLAAVVVNPSVKTVR	98.71
5	ITYTDVLRY TLARGFPFV KSYETEYPK; SYHDRRWCF MPNGLIAQF	VTVNPFVSVATANAKVLI; ILVSLAAVVVNPSVKTVR	99.01
6	ITYTDVLRY TLARGFPFV KSYETEYPK; SYHDRRWCF MPNGLIAQF GPIRFVLAL; AEVEEHRTV MTTEDMLEVW RSLFGGMSW	VTVNPFVSVATANAKVLI; ILVSLAAVVVNPSVKTVR	99.52