West Nile Virus Vaccine Design by T Cell Epitope Selection: In Silico Analysis of Conservation, Functional Cross-Reactivity with the Human Genome, and Population Coverage

Table 3

Subset of epitopes that represent all HLA-II alleles by elimination of repetitive binding profiles.

Epitope	HLA-II binding profile top 5 percentile rank	PPC
VTVNPFVSVATANAKVLI	HLA-DRB108:02, HLA-DRB104:01, HLA-DRB109:01, HLA-DRB111:01, HLA-DRB104:05, HLA-DRB101:01, HLA-DRB302:02, HLA-DRB501:01, HLA-DRB107:01, HLA-DRB113:02, HLA-DRB115:01, HLA-DQA101:02/DQB106:02	70.55
ILVSLAAVVVNPSVKTVR	HLA-DRB108:02, HLA-DRB101:01, HLA-DRB103:01, HLA-DRB104:01, HLA-DQA101:02/DQB106:02, HLA-DRB112:01, HLA-DRB104:05, HLA-DRB115:01, HLA-DRB113:02, HLA-DQA105:01/DQB103:01, HLA-DRB111:01, HLA-DRB302:02	69.22
RVVFVVLLLLVAPAYS	HLA-DPA103:01/DPB104:02, HLA-DPA102:01/DPB101:01, HLA-DRB111:01, HLA-DPA101:03/DPB102:01, HLA-DPA101/DPB104:01, HLA-DRB112:01, HLA-DRB108:02, HLA-DRB115:01, HLA-DRB104:01, HLA-DRB104:05, HLA-DPA102:01/DPB105:01, HLA-DRB101:01, HLA-DRB301:01, HLA-DRB501:01, HLA-DRB103:01, HLA-DQA105:01/DQB102:01	65.33
SGNVVHSVNMTSQVLLGR	HLA-DRB103:01, HLA-DRB107:01, HLA-DRB104:05, HLA-DRB104:01, HLA-DRB111:01, HLA-DQA101:02/DQB106:02, HLA-DRB108:02, HLA-DRB113:02, HLA-DRB401:01, HLA-DRB104:01	59.32
VLSLIGLKRAMLSLIDGK	HLA-DRB108:02, HLA-DRB111:01, HLA-DRB109:01, HLA-DRB501:01, HLA-DRB103:01, HLA-DPA102:01/DPB114:01, HLA-DRB401:01, HLA-DRB302:02, HLA-DRB115:01, HLA-DPA102:01/DPB101:01	49.41
LVQSYGWNIVTMKSGVDV	HLA-DRB107:01, HLA-DRB501:01, HLA-DQA101:01/DQB105:01, HLA-DRB115:01	34.78
GLLGSYQAGAGVMVEGVF	HLA-DRB109:01, HLA-DQA104:01/DQB104:02, HLA-DQA103:01/DQB103:02, HLA-DRB107:01, HLA-DQA101:02/DQB106:02, HLA-DQA105:01/DQB103:01, HLA-DRB101:01	34.02