Single Nucleotide Polymorphisms in TLR4 Affect Susceptibility to Tuberculosis in Mexican Population from the State of Veracruz
Table 1
Demographic characteristics of cases and controls.
TB cases
Controls
OR (95% CI)
value
Median age (years) (range)
37 (18-97)
38 (18-97)
—
0.13
Gender
Female (%)
107 (38.4)
410 (72.1)
1
Reference
Male (%)
172 (61.6)
159 (27.9)
4.15 (3.03-5.68)
<0.001
Smoking (%)
No
254 (91.1)
505 (88.8)
1
Reference
Yes
25 (8.9)
64 (11.2)
0.75 (0.46-1.29)
0.24
Alcohol use (%)
No
232 (83.3)
455 (80.0)
1
Reference
Yes
47 (16.7)
114 (20.0)
0.80 (0.54-1.19)
0.20
Direct contact with patients
No
21 (7.5)
46 (8.1)
Reference
Yes
257 (92.1)
516 (90.7)
1.09 (0.62 - 1.97)
0.89
Unknown
1 (0.4)
7 (1.2)
Living in a rural area (%)
No
205 (74.2)
447 (78.6)
1
Reference
Yes
74 (26.3)
122 (21.4)
1.32 (0.93-1.86)
0.10
Speak an indigenous language (%)
No
229 (82.1)
514 (90.3)
1
Reference
Yes
50 (17.9)
55 (9.7)
2.04 (1.33-3.15)
<0.001
Educational level (%)
Higher
15 (5.4)
133 (23.4)
Complete high school
41 (14.7)
109 (19.2)
Complete secondary school
71 (25.4)
127 (22.3)
1
Reference
Complete elementary school
100 (35.8)
145 (25.5)
None
52 (18.6)
55 (9.7)
2.22 (1.66-2.97)
<0.0001
Abbreviations: TB: tuberculosis; OR: odds ratio; CI: confidence interval. value for age was calculated by Wilcoxon 2-sample rank-sum test. OR and 95% CI and values for all other characteristics were assessed by using univariate logistic regression.
