Reverse Immunology Approach to Define a New HIV-gp41-Neutralizing Epitope

Figure 4

Molecular interaction between the F8 mAb and peptides. The target peptides are indicated in the first column. The amino acid sequences of both the VL and the VH domains are indicated in the second column. CDRs are underlined and indicated in bold letters while residues involved in the interaction with the peptide are indicated in red. The closest F8 germline-encoded V regions, identified in Supplemental Table I, are indicated in blue.