Mutated p53 Promotes the Symmetric Self-Renewal of Cisplatin-Resistant Lung Cancer Stem-Like Cells and Inhibits the Recruitment of Macrophages

<div>mt p53 promotes the symmetric cell division of cisplatin-resistant stem cell-like NSCLC cells. (a) Forced expression of wt p53 and mt p53 in p53 null H1299/CisR cells. Western blot analysis of lysates from H1299/Cr, H1299/Cr-wt-p53, and H1299/Cr-mt-p53 cells using an anti-p53 antibody. GAPDH was used as an internal control. (b, c) Fluorescence microscopy for the analysis of the division of CD44<sup>+</sup>/CD90<sup>+</sup> LCSCs isolated from H1299/Cr-wt-p53 and H1299/Cr-mt-p53 cells following cell seeding.</div>

Journal of Immunology Research

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Figure 4

Figure 4: Mutated p53 Promotes the Symmetric Self-Renewal of Cisplatin-Resistant Lung Cancer Stem-Like Cells and Inhibits the Recruitment of Macrophages 

Figure 4 | Mutated p53 Promotes the Symmetric Self-Renewal of Cisplatin-Resistant Lung Cancer Stem-Like Cells and Inhibits the Recruitment of Macrophages 