C/EBP Homologous Protein (CHOP) Activates Macrophages and Promotes Liver Fibrosis in Schistosoma japonicum-Infected Mice

Figure 1

Liver fibrosis is aggravated by S. japonicum infection. The animals were infected with S. japonicum cercariae. HE staining, Masson trichrome staining, and immunohistochemistry were used to observe the pathological changes and collagen deposition of liver tissue. (a) The morphology changes on the liver of S. japonicum infection in mice. (b) Liver tissues were stained with HE. Arrows indicate granulomatous lesions and arrowheads indicate schistosome eggs (magnified ×200). (c) The protein expression of fibronectin detected by immunohistochemistry (magnified ×400). (d) Liver tissues were stained with Masson’s trichrome staining (magnified ×200). (e) Liver/body ratio of the infection group and the control group after S. japonicum cercariae. (f) Areas of single egg granulomas. (g) The quantitative analysis of fibronectin in liver tissues. (h) Average optical density of the collagen deposition in liver tissues. Data were presented as of 6-8 mice. and vs. the control. ^# and ^## vs. the 6-week infection group.

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