Potential Effect of Statins on Mycobacterium tuberculosis Infection

Table 3

Retrospective studies of statin use in humans and the risk of developing tuberculosis.

Author	Year	Method	Patients	Conclusions
Kang et al.	2014	Retrospective cohort study	840,894 newly diagnosed type 2 DM patients aged 20-99 years who were newly treated with antidiabetic drugs	Statin use in newly diagnosed type 2 diabetics was not associated with protection against or a higher risk of developing tuberculosis
Lee et al.	2015	Retrospective cohort study	13,981 patients with type 2 diabetes aged more than 65 years	After adjusting for age, sex, other comorbidities, and medications, statin users had a lower independent association, with a risk ratio of 0.76 (95% CI, 0.60-0.97)
Lai et al.	2016	Retrospective nested case-control study	8098 new TB cases and 809,800 control patients	Statin users had a decreased risk of active tuberculosis. Chronic use of statins (more than 90 days) was associated with the lowest risk (RR 0.62; 95% CI 0.53-0.72)
Su et al.	2017	Retrospective nested case-control study	102,424 statin users, 202,718 patients aged 20 years or older, and 202,718 matched subjects	Statin use is an independent protective factor for tuberculosis development. There is a dose-dependent association between statin use and risk of active tuberculosis