Journal of Immunology Research / 2018 / Article / Tab 3

Review Article

Potential Effect of Statins on Mycobacterium tuberculosis Infection

Table 3

Retrospective studies of statin use in humans and the risk of developing tuberculosis.

AuthorYearMethodPatientsConclusions

Kang et al.2014Retrospective cohort study840,894 newly diagnosed type 2 DM patients aged 20-99 years who were newly treated with antidiabetic drugsStatin use in newly diagnosed type 2 diabetics was not associated with protection against or a higher risk of developing tuberculosis
Lee et al.2015Retrospective cohort study13,981 patients with type 2 diabetes aged more than 65 yearsAfter adjusting for age, sex, other comorbidities, and medications, statin users had a lower independent association, with a risk ratio of 0.76 (95% CI, 0.60-0.97)
Lai et al.2016Retrospective nested case-control study8098 new TB cases and 809,800 control patientsStatin users had a decreased risk of active tuberculosis. Chronic use of statins (more than 90 days) was associated with the lowest risk (RR 0.62; 95% CI 0.53-0.72)
Su et al.2017Retrospective nested case-control study102,424 statin users, 202,718 patients aged 20 years or older, and 202,718 matched subjectsStatin use is an independent protective factor for tuberculosis development. There is a dose-dependent association between statin use and risk of active tuberculosis

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