Immunomodulatory Effect of Flavonoids of Blueberry (<i>Vaccinium corymbosum</i> L.) Leaves via the NF-<i>κ</i>B Signal Pathway in LPS-Stimulated RAW 264.7 Cells

<div>Effects of FBL on TNF-<i>α</i> levels in LPS-stimulated RAW 264.7 cells. Control group treated without LPS and FBL; model group treated with only 1 <i>μ</i>g/mL LPS for 24 h; positive group treated with 44.70 mg/mL indometacin for 6 h and 1 <i>μ</i>g/mL LPS for 24 h; and FBL groups treated with 62.50, 15.62, and 3.91 <i>μ</i>g/mL FBL for 6 h, respectively, and 1 <i>μ</i>g/mL LPS for 24 h. <svg height="10.7395pt" id="M27" style="vertical-align:-0.6370001pt" version="1.1" viewbox="-0.0498162 -10.1025 50.9184 10.7395" width="50.9184pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.0091,0,0,-0.0091,0,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 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124 313S148 602 238 602Z" id="g113-49"></path></g><g transform="matrix(.013,0,0,-0.013,47.76,0)"><path d="M384 0V27C293 34 287 42 287 114V635C232 613 172 594 109 583V559L157 557C201 555 205 550 205 499V114C205 42 199 34 109 27V0H384Z" id="g113-50"></path></g></svg> versus medium-dose FBL group.</div>

Journal of Immunology Research

fig3

Figure 3

Figure 3: Immunomodulatory Effect of Flavonoids of Blueberry (<i>Vaccinium corymbosum</i> L.) Leaves via the NF-<i>κ</i>B Signal Pathway in LPS-Stimulated RAW 264.7 Cells 

Figure 3 | Immunomodulatory Effect of Flavonoids of Blueberry (Vaccinium corymbosum L.) Leaves via the NF-κB Signal Pathway in LPS-Stimulated RAW 264.7 Cells 