The Role of NK Cells in Pig-to-Human Xenotransplantation
Table 1
Integrins and selectins and their ligands involved in NK cell recruitment to pig endothelium [30, 186].
Protein family
Name
CD name
Heterodimer
Receptor location
Ligands
Ligand CD name
Ligand location
Cross-species interaction
Integrins
α4
CD49d
α4/β1
NK
VCAM-1 fibronectin
CD106 —
pECs ECM
Yes Yes
α4/β7
NK
VCAM-1 MadCAM-1
CD106 —
pEC EC (pEC?)
Yes U
α6
CD49f
α6/β1
NK
Laminin
—
ECM
No
αL, LFA-1
CD11a
αL/β2
NK
ICAM-1 ICAM-2
CD54 CD102
pECs pECs
Yes U
αM, Mac-1
CD11b
αM/β2
NK
ICAM-3 RAGE
CD50 —
pECs ST
Yes U
β1
CD29
α4/β1
See above
α6/β1
See above
β2
CD18
αL/β2
See above
†Integrin dimers
VLA-4
CD49d/CD29
α4/β1
See above
VLA-6
CD49f/CD29
α6/β1
See above
LPAM-1
—
α4/β7
See above
Selectins
E-selectin
CD62E
—
pECs
PSGL-1 sialyl LewisX Sialophoryn
CD162 CD15s CD43
pECs NK NK
No U U
L-selectin
CD62L
—
NK
Mucosialin MadCAM-1 GlyCAM-1
CD34 — —
pEC pECs
Yes
P-selectin
CD62P
—
pECs
PSGL-1 Sialyl LewisX
CD162 CD15s
NK NK
No U
pMIC2?
pCD99?
—
pECs
MIC2, E2
CD99
NK
Yes
Adhesion molecules
PECAM-1
CD31
—
pECs
PECAM-1
CD31
NK
No
Cell on which the molecule is expressed. †Integrins exist as heterodimers and are composed of one α and one β unit. CD: cluster of differentiation; ECM: extracellular matrix; NK: human natural killer cells; pEC: pig endothelial cells; ST: several tissues; U: unknown.
