Comparison between the HLA-B58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions

Table 3

Properties of proposed genetic screening tests for prediction of allopurinol-induced SCARs in a Thai population.

Allele/SNPs	Sensitivity (%)			Specificity (%)			PPV (%)			NPV (%)
	DRESS	SJS/TEN	SCARs	DRESS	SJS/TEN	SCARs	DRESS	SJS/TEN	SCARs	DRESS	SJS/TEN	SCARs
HLA-B58 : 01	91.30	94.52	93.75	88.08	88.08	88.08	47.73	75.00	79.65	98.84	97.70	96.59
rs9263726 (G/A)	82.61	93.15	90.63	82.38	82.38	82.38	35.85	66.67	71.90	97.55	96.95	94.64
rs2734583 (T/C)	91.30	90.41	90.63	86.01	86.01	86.01	43.75	70.97	76.32	98.81	95.95	94.86
rs3099844 (C/A)	91.30	90.41	90.63	84.97	84.97	84.97	42.00	69.47	75.00	98.80	95.91	94.80
SNPs haplotypes (rs9263726-rs2734583-rs3099844)
GA-TC-CA	69.57	83.56	80.21	87.56	87.56	87.56	40.00	71.76	76.24	96.02	93.37	89.89

Data presented as percentage. PPV: positive predictive value; NPV: negative predictive value.