Comparison between the HLA-B58 : 01 Allele and Single-Nucleotide Polymorphisms in Chromosome 6 for Prediction of Allopurinol-Induced Severe Cutaneous Adverse Reactions
Table 2
Univariate analysis of the association between HLA-B58 : 01 allele and SNPs with allopurinol-induced SCARs.
Allele/SNPs
Control ()
DRESS ()
SJS/TEN ()
SCARs ()
n (%)
n (%)
OR [95% CI] Pc-value
n (%)
OR [95% CI] Pc-value
n (%)
OR [95% CI] Pc-value
HLA-B58 : 01
Negative
170 (88.08)
2 (8.70)
Reference
4 (5.48)
Reference
6 (6.25)
Reference
Positive
23 (11.92)
21 (91.30)
77.61 [17.07–352.85] 7.12 × 10−8
69 (94.52)
127.50 [42.53–382.27] 1.99 × 10−17
90 (93.75)
110.87 [43.57–282.15] 2.05 × 10−22
rs9263726 (G/A)
Negative (GG)
159 (82.38)
4 (17.39)
Reference
5 (6.85)
Reference
9 (9.38)
Reference
Positive (GA/AA)
34 (17.62)
19 (82.61)
22.21 [7.10–69.46] 3.91 × 10−7
68 (93.15)
63.60 [23.85–169.56] 4.22 × 10−16
87 (90.63)
45.21 [20.73–98.60] 3.92 × 10−21
rs2734583 (T/C)
Negative (TT)
166 (86.01)
2 (8.70)
Reference
7 (9.59)
Reference
9 (9.37)
Reference
Positive (TC/CC)
27 (13.99)
21 (91.30)
64.56 [14.31–291.16] 2.35 × 10−7
66 (90.41)
57.97 [24.07–139.60] 5.51 × 10−19
87 (90.63)
59.43 [26.76–131.97] 4.24 × 10−23
rs3099844 (C/A)
Negative (CC)
164 (84.97)
2 (8.70)
Reference
7 (9.59)
Reference
9 (9.38)
Reference
Positive (CA/AA)
29 (15.03)
21 (91.30)
59.38 [13.21–266.97] 4.04 × 10−7
66 (90.41)
53.32 [22.26–127.71] 1.82 × 10−18
87 (90.63)
54.67 [22.77–120.66] 1.58 × 10−22
SNPs haplotypes (rs9263726-rs2734583-rs3099844)
GG-TT-CC
156 (80.83)
2 (8.70)
Reference
4 (5.48)
Reference
6 (6.25)
Reference
GA-TC-CA
24 (12.44)
16 (69.57)
52.00 [11.24–240.51] 1.17 × 10−6
61 (83.56)
99.13 [33.03–297.52] 9.90 × 10−16
77 (80.21)
83.42 [32.74–212.55] 7.43 × 10−20
Pc-value: Bonferroni-corrected value, calculated by multiplying value by 4 which is the number of detected SNPs.