Fundamentals and Methods for T- and B-Cell Epitope Prediction

Figure 1

B-cell epitope recognition. B-cell epitopes are solvent-exposed portions of the antigen that bind to secreted and cell-bound immunoglobulins. (a) B-cell receptors encompass cell-bound immunoglobulins, consisting of two heavy chains and two light chains. The different chains and regions are annotated. (b) Molecular representation of the interaction between an antibody and the antigen. Antibodies are secreted immunoglobulins of known specificity.

(a)

(b)