Review Article
The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape
Table 2
Abnormality of DNA methylation in RASFs.
| Epigenetic alterations | Function | References |
| Global genomic hypomethylation and decrease of DNMT1 protein expression | Increase of 186 gene expressions | [93] | Normal DNMT1 gene expression | Decrease of DNMT1 gene expression after IL-1 stimulation | [94] | Hypermethylation | Decrease of DR3 involved in resistance to apoptosis | [95] | Hypomethylation | Increase of TBX5 involved in chemokine production | [86] | Hypomethylation | Increase of CXCL12 involved in inflammation | [96] | Genome-wide differential methylation | 1859 differentially methylated loci | [97] | Genome-wide differential methylation | 2375 differentially methylated loci | [98] |
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