Review Article
The Mechanisms Underlying Chronic Inflammation in Rheumatoid Arthritis from the Perspective of the Epigenetic Landscape
Table 1
Abnormality of histone modifications in RASFs.
| Epigenetic alterations | Function | References |
| Increase of H3K27me3 by upregulated EZH2 | Decrease of SFRP1 involved in Wnt signaling inhibition | [85] | Increase of H3K4me3, decrease of H3K27me3, and increase of H3ac | Increase of TBX5 involved in chemokine production | [86] | Increase of H3K4me3 and decrease of H3K27me3 | Increase of MMP-1, MMP-3, MMP-9, and MMP-13 involved in extracellular matrix degradation | [87] | Increase of H3ac | Increase of IL-6 involved in inflammation | [88] | Decrease of HDAC activity and expression | Histone hyperacetylation | [89] | Increase of HDAC activity and expression | Histone hypoacetylation | [90] |
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