Actions of Thyroid Hormone Analogues on Chemokines

Figure 1

Highly correlated patterns of nanoparticulate tetrac (Nanotetrac) treatment of human breast and thyroid cancer cells on abundance of mRNAs of selected chemokine ligands and receptors. Shown are average values ( transformed) of biological replicates of microarray analyses. Microarray gene expression methodology and data analysis pipelines are as previously reported [23, 24]. Use of two CXCR4 probes verified responsiveness to Nanotetrac of the intact gene and a variant of this chemokine. , correlation coefficient; , coefficient of determination used to estimate accuracy of the data model; , results of linear regression analysis (regression line equation).