Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Table 1

List of selected proinflammatory cytokines contributing to the development of chronic inflammatory disorders.

Cytokine	Cell recruitment	Chronic inflammatory disorders
TNFα	Monocytes, neutrophils, and dendritic cells	RA [13], IBD [18], A [19], and COPD [20]
IL1α	Neutrophils, T cells	RA [21], IBD [22]
IL1β	Neutrophils, thrombocytes, and T cells	RA [13]
IL6	Neutrophils, B cells	RA [13], A [23], and COPD [24]
IL12β	T cells	RA [25], IBD [26], and A [27]
CCL2	Monocytes, dendritic cells, and memory T cells	RA [21], A [28]
CCL3	Neutrophils, eosinophils, and basophils	RA [29], A [30]
CCL4	Monocytes, dendritic cells, NK cells, and T cells	RA [31], IBD [32], and A [30]
CCL5	Eosinophils, basophils, and T cells	RA [33], A [30]
IL8	Neutrophils, macrophages, and mast cells	RA [13], A [28], and IBD [34]

RA = rheumatoid arthritis, IBD = inflammatory bowel disease, A = atherosclerosis, and COPD = chronic obstructive pulmonary disease.