Research Article

Regulation of Neutrophil Degranulation and Cytokine Secretion: A Novel Model Approach Based on Linear Fitting

Figure 4

Linear fitting approach to investigate time series of degranulation and cytokine secretion. (a) Simulations were performed to find the optimal threshold for RSQ value. After introducing perturbations ( value) to the kinetic profiles, the linear fitting decreases in significance. (b) Plot of average RSQ deriving from simulations against augmenting values. (c) Perfectly linear fitting model in which the behaviour of IL8 is correlated to CD11b. Due to its value of 0 and RSQ of 0.91, the correlation between IL8 and CD11b corresponds to a perfect linear fitting model.