Towards Targeted Delivery Systems: Ligand Conjugation Strategies for mRNA Nanoparticle Tumor Vaccines

Figure 2

The genetic vaccination model. Antigen presentation occurs directly by transfected DCs through gene expression of the antigen. DCs also cross present antigens secreted by transfected bystander cells, or derived from phagocytosis of apoptotic cells. Cross presentation mechanisms in DCs may facilitate delayed lysosomal delivery leading to higher delivery efficiencies.