Inhibition of Neutrophil Collagenase/MMP-8 and Gelatinase B/MMP-9 and Protection against Endotoxin Shock

Table 1

Peptide sequences and their IC50 values in μM against target enzymes.

Peptide name	Peptide sequence	MMP-8	MMP-9	TACE	Reference
Regasepin 2	Pro-Pyr-Cys-Bip-Arg-Gly-Glu	10	0.8	1.5	[9]
Regasepin 1	Pro-Arg-Cys-Bip-Cys-Gly-Glu	3	1.5	5	[8]
Inhibitor 2	Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu	0.8	2.75	5.5	[11]
ES-2	Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro	>500	>500	>500	[10]
P2	Pro-(D-Pyr)-(D-Cys)-Bip-Arg-Gly-Glu-Gly-Gly-Gly-Gly-Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro	0.35	1.36	1.95	[10]
HM-3	Ile-Val-Arg-Arg-Ala-Asp-Arg-Ala-Ala-Val-Pro-Gly-Gly-Gly-Gly-Arg-Gly-Asp	ND	ND	ND	[12]