The Secretion of IL-22 from Mucosal NKp44⁺ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIV/SHIV-Infected Chinese Macaques

Table 1

Summary of viruses and associated experimental parameters used in the first part of the study.

Animal number	Sex	Virus stock	Dose (TCID50)	Route of infection	Plasma viral load (copies/mL)	Peripheral CD4 T cells (cells/μL)	Plasma LPS (EU/mL)	Plasma LBP (mg/mL)	Group
G1005V	♀	SHIV-; 1157ipd3N4	50	IV	<100	606	0.310	9.554	MT^high
G1006V	♀		50	IV	291	1271	0.105	2.667	MT^low
G1007V	♀		50	IV	<100	2271	0.095	4.327	/
G1008V	♀		5	IV	<100	2172	0.310	9.554	MT^high
G1009V	♀		5	IV	327	867	0.125	6.649	/
G1010V	♀		5	IV	<100	592	0.095	1.952	MT^low
G1011V	♀	SHIV-KB9	500	IV	13240	1277	0.525	7.309	MT^high
G1012V	♀		50	IV	<100	674	0.095	4.879	/
G1013V	♀		5	IV	<100	866	0.100	5.515	/
G1014V	♀		1000	IV	411	1287	0.085	2.562	MT^low
G1015R	♀	SHIV-; 1157ipd3N4	20	IR (repeated 4)	289	1931	0.140	4.718	/
G1016R	♂		20	IR (repeated 4)	660	875	0.085	2.590	MT^low
G1017R	♂		20	IR (repeated 6)	1387	978	0.090	2.177	MT^low
G1018R	♂		20	IR (repeated 5)	772	2707	0.105	5.988	/
G1019R	♀		20	IR (repeated 4)	13555	431	0.545	9.554	MT^high
G1020R	♀		20	IR (repeated 10)	<100	2075	0.110	2.351	/
G1021R	♀		20	IR (repeated 10)	<100	1093	0.090	3.317	MT^low
G1022R	♀		20	IR (repeated 4)	185	1869	0.090	6.195	/
G1023R	♂		20	IR (repeated 13)	<100	1446	0.615	7.058	MT^high
G1024R	♂		20	IR (repeated 10)	2776	3127	0.850	9.554	MT^high

IR: intrarectal; IV: intravenous; LBP: lipopolysaccharide-binding protein; LPS: lipopolysaccharide, MT: microbial translocation; SHIV: simian human immunodeficiency virus.