The Secretion of IL-22 from Mucosal NKp44⁺ NK Cells Is Associated with Microbial Translocation and Virus Infection in SIV/SHIV-Infected Chinese Macaques

Figure 4

Percentage and function of natural killer (NK)p44⁺ cell subsets are altered in the microbial translocation and groups. Frequency of (a) NKp44⁺ NK cells and (b) NKG2A⁺NKp44⁺ NK cells in peripheral and mucosal tissues from the and groups. The expressions of IL-22, IFN-γ, and CD107a of NKp44⁺ NK cells were compared between the and groups in (c) Peyer’s patches mononuclear cells (PPMCs) and (d) lamina propria mononuclear cells (LPMCs). The column bar indicates the mean of the ratio of target cells (mononuclear cells in (a) and (b); NKp44⁺ NK cells in (c) and (d)). Error bars and individual standard deviations (SD) are shown. Spearman correlation test showed that the number of IL-22⁺NKp44⁺ NK cells in PPMCs and LMPCs correlated well with plasma lipopolysaccharide (LPS) levels. and as calculated by two-sided nonparametric Mann-Whitney test.

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